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High-Gain Calibration

Meaning

High-Gain Calibration is a term borrowed from control systems engineering and applied metaphorically to describe the process of optimizing a biological feedback loop to achieve maximum sensitivity and precision in response to minimal input fluctuations. In endocrinology, this signifies an exquisitely tuned system, such as the HPT or HPA axis, where the receptor-effector pathway exhibits a robust, high-amplitude response to small changes in circulating hormone levels. This calibrated state represents a pinnacle of physiological efficiency and responsiveness.