What is the Origin of High-Frequency Dosing?

This methodology is borrowed from pharmacokinetic principles where achieving steady-state drug levels is critical for therapeutic effect. Its adoption in hormone therapy reflects a deeper understanding of receptor saturation dynamics and pulsatile signaling. The frequency of administration becomes a key variable in optimizing bioavailability.

What is the Mechanism of High-Frequency Dosing?

The mechanism centers on saturating receptor sites consistently throughout the biological cycle, preventing periods of receptor under-stimulation or potential downregulation from sudden high concentrations. By keeping the effective concentration within a narrow therapeutic window, cellular signaling remains continuous and robust. This minimizes metabolic clearance fluctuations that can compromise the intended physiological adjustment.

High-Frequency Dosing

Meaning

A therapeutic administration strategy involving the repeated, often smaller, delivery of a substance over shorter intervals, contrasting with traditional once-daily or weekly regimens. Within hormonal science, this technique is employed to maintain stable plasma concentrations of active compounds, avoiding peaks and troughs associated with single large doses. This approach seeks to mimic more physiological hormone release patterns. Precision in timing is essential for efficacy and safety.