A High-Fidelity Signal describes a hormonal or molecular communication event that is transmitted from the source to the target cell with minimal degradation, distortion, or noise in the signaling pathway. It represents optimal communication integrity.
Origin
Borrowed from audio engineering where “high fidelity” denotes accurate reproduction of the original source, this term is applied here to molecular signaling to denote accuracy in endocrine communication. We seek fidelity in our hormonal messages.
Mechanism
Achieving a high-fidelity signal requires intact receptor structure, efficient second messenger function, and appropriate concentrations of necessary cofactors, ensuring the cellular response precisely mirrors the initial endocrine command. Attenuation or interference in these steps reduces signal fidelity, leading to functional deficit.
We use cookies to personalize content and marketing, and to analyze our traffic. This helps us maintain the quality of our free resources. manage your preferences below.
Detailed Cookie Preferences
This helps support our free resources through personalized marketing efforts and promotions.
Analytics cookies help us understand how visitors interact with our website, improving user experience and website performance.
Personalization cookies enable us to customize the content and features of our site based on your interactions, offering a more tailored experience.