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High-Fidelity Biological Response

Meaning

High-fidelity biological response refers to a cellular or systemic reaction that is precisely accurate and directly proportional to the original biochemical signal, characterized by minimal signal loss or distortion in the communication pathway. In the hormonal context, this means a hormone’s message is received and executed with maximum accuracy by its target receptor, leading to the exact intended physiological outcome. Maintaining this high-fidelity signaling is essential for robust homeostasis, as aging and chronic pathology often introduce “noise,” resulting in a blunted or erratic response known as receptor desensitization.