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High-Dose Vitamin D Therapy

Meaning

High-Dose Vitamin D Therapy is a specific clinical intervention involving the administration of Vitamin D (typically as cholecalciferol, Vitamin D3) at doses significantly exceeding standard daily recommendations, often to correct severe deficiency or to achieve specific therapeutic serum levels. This approach is employed when standard supplementation fails to reach optimal 25-hydroxyvitamin D concentrations, which are crucial for immune modulation, bone health, and endocrine function. Due to the hormone-like activity of Vitamin D, this therapy requires rigorous laboratory monitoring to ensure efficacy and prevent toxicity, particularly hypercalcemia.