What is the Origin of High-Dose NAD+ Therapy?

The therapy is derived from decades of research into cellular metabolism and the role of NAD+ in aging, a concept pioneered in the early 20th century but significantly revitalized by modern longevity science. The 'high-dose' application is a clinical development aimed at overcoming the limitations of oral precursors by achieving immediate, high systemic bioavailability.

What is the Mechanism of High-Dose NAD+ Therapy?

NAD+ is an essential coenzyme for hundreds of cellular reactions, serving as a critical substrate for enzymes like sirtuins (SIRT) and poly-ADP-ribose polymerases (PARPs), which are central to DNA repair and stress resistance. By administering high doses, the therapy attempts to saturate cellular pathways, effectively boosting the activity of these longevity-associated enzymes and improving overall cellular energy status and hormonal signaling responsiveness.

High-Dose NAD+ Therapy ∞ Area

High-Dose NAD+ Therapy

Meaning

High-Dose NAD+ Therapy involves the therapeutic administration of high concentrations of Nicotinamide Adenine Dinucleotide (NAD+), typically via intravenous infusion, to rapidly elevate systemic and cellular NAD+ levels. This intervention is employed to replenish the coenzyme pools that naturally decline with age, supporting crucial metabolic processes, enhancing mitochondrial function, and promoting DNA repair. It is a strategy utilized in advanced longevity and metabolic health protocols.