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High-Amplitude Pulses

Meaning

In endocrinology, High-Amplitude Pulses describe a pattern of hormone secretion characterized by a large, rapid surge in hormone concentration, which is distinct from the low-level, tonic, or basal secretion. This pulsatile release is a fundamental and necessary mode of communication for several key hormones, including Gonadotropin-Releasing Hormone (GnRH) and Growth Hormone (GH). The amplitude and frequency of these pulses are tightly regulated and convey specific biological messages to target tissues. Clinically, the measurement and manipulation of these pulse characteristics are essential for managing reproductive and growth hormone axis disorders.