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Heritable Genetic Modification

Meaning

Heritable genetic modification, often referred to as germline editing, involves intentionally altering the DNA within reproductive cells, such as sperm or eggs, or in the early cells of an embryo. Crucially, any genetic change made using this technique is then passed down to all subsequent generations of offspring, making the alteration permanent in the lineage. This represents a profound and irreversible intervention with significant long-term biological and ethical implications, distinct from non-heritable somatic cell gene therapy.