What is the Origin of Hepatocellular Adenoma?

The term is derived from Greek and Latin: Hepato- (liver), cellula (small cell), and adenoma (glandular tumor). Its clinical association with exogenous hormones became apparent in the mid-20th century, linking pharmacological interventions with a specific hepatic pathology.

What is the Mechanism of Hepatocellular Adenoma?

The mechanism is primarily driven by the proliferative and anti-apoptotic effects of sex steroids on hepatocytes. Androgens and estrogens can act as mitogens, promoting the growth of abnormal cell clones. The specific structural modifications of some oral hormones, which increase hepatic exposure, are thought to exacerbate this pro-proliferative effect, leading to the clonal expansion that forms the macroscopic adenoma.

Hepatocellular Adenoma ∞ Area

Hepatocellular Adenoma

Meaning

A rare, benign epithelial tumor of the liver that originates from hepatocytes, the main functional cells of the liver. In the context of hormonal health, these tumors are clinically significant because they are strongly associated with exposure to exogenous sex steroids, particularly high-dose oral contraceptives and C-17-alpha alkylated androgens. Though typically benign, they carry a risk of hemorrhage or malignant transformation.