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Hepatic Lipogenesis

Meaning

Hepatic lipogenesis is the fundamental metabolic pathway occurring primarily in the liver, responsible for synthesizing fatty acids from non-lipid precursors, most notably excess dietary carbohydrates. This process is a crucial component of energy storage and substrate partitioning, linking nutritional intake to lipid production. In the context of hormonal health, the rate of hepatic lipogenesis is tightly regulated by key endocrine signals, particularly insulin and thyroid hormones, and its dysregulation contributes significantly to the development of non-alcoholic fatty liver disease (NAFLD) and systemic metabolic syndrome.