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Hepatic Lipid Synthesis

Meaning

Hepatic Lipid Synthesis is the fundamental biochemical process occurring primarily within the liver where fatty acids, triglycerides, and cholesterol are manufactured de novo from non-lipid precursors, most commonly from excess dietary carbohydrates. This essential metabolic pathway is central to systemic energy storage and the necessary production of vital structural and signaling molecules, including the cholesterol precursor required for all steroid hormones. Excessive or pathologically dysregulated synthesis is a major, recognized contributor to non-alcoholic fatty liver disease and significant dyslipidemia, conditions that profoundly impair insulin sensitivity and disrupt systemic hormonal balance. Clinical management often focuses on carefully modulating this synthesis pathway to improve overall metabolic health and reduce cardiovascular risk.