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Hepatic Lipid Homeostasis

Meaning

Hepatic lipid homeostasis refers to the highly regulated physiological process by which the liver maintains a precise balance between the synthesis, uptake, storage, and export of various lipids, including triglycerides and cholesterol. This metabolic equilibrium is crucial for overall systemic health, as the liver acts as the central hub for energy distribution and detoxification. Disruption of this homeostasis, often driven by insulin resistance or hormonal imbalance, can lead to conditions such as Non-Alcoholic Fatty Liver Disease (NAFLD). Clinically, maintaining this balance is paramount for preventing cardiovascular and metabolic dysfunction.