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Hepatic Glucose Output Regulation

Meaning

Hepatic Glucose Output Regulation is the homeostatic process by which the liver precisely controls the release of glucose into the systemic circulation to maintain stable blood glucose levels, particularly during periods of fasting or between meals. This regulation involves a complex interplay of hormonal signals, primarily insulin and glucagon, which modulate the rates of glycogenolysis and gluconeogenesis within the hepatocytes. Clinical disturbances in this process, such as excessive nocturnal glucose output, are characteristic features of insulin resistance and type 2 diabetes pathology.