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Hepatic-Cerebral Axis

Meaning

The Hepatic-Cerebral Axis refers to the intricate, bidirectional communication network connecting the liver (hepatic system) and the central nervous system (cerebral system), playing a pivotal role in metabolic and energy homeostasis. This axis involves the exchange of hormonal, neural, and metabolic signals that influence appetite regulation, glucose metabolism, and systemic inflammation. The liver, as the primary metabolic clearinghouse, signals its nutritional and inflammatory status to the brain, which in turn modulates hepatic function through autonomic and endocrine pathways. Dysfunction in this axis is increasingly recognized in conditions like metabolic syndrome and neurodegenerative disorders.