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Hepatic Bypass Modality

Meaning

Hepatic Bypass Modality describes a method of hormone administration that intentionally circumvents the portal circulation and the initial metabolic breakdown that occurs upon first-pass transit through the liver. This clinical strategy is employed to deliver the active hormone directly into the systemic circulation, ensuring a higher bioavailability and reducing the liver’s exposure to high concentrations of the compound. The modality is crucial for managing the downstream effects on hepatic protein synthesis.