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Hepatic Biotransformation

Meaning

Hepatic biotransformation, also known as drug metabolism, is the critical detoxification process carried out primarily by the liver, which chemically modifies endogenous compounds like hormones and exogenous substances such as pharmaceuticals and environmental toxins. This complex enzymatic process transforms lipophilic (fat-soluble) molecules into more polar, water-soluble metabolites that can be readily excreted by the kidneys or in the bile. Efficient biotransformation is paramount for preventing the accumulation of active or toxic compounds, thereby maintaining systemic health and protecting against cellular damage. A compromised liver function can profoundly disrupt hormonal balance and overall wellness.