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Heat Shock Proteins Brain

Meaning

Heat Shock Proteins Brain refers to a specific family of highly conserved proteins expressed by all cells, including neurons and glial cells in the brain, in rapid response to various cellular stressors, such as hyperthermia, oxidative stress, or chronic inflammation. These Heat Shock Proteins (HSPs) function as essential molecular chaperones, assisting in the proper folding of nascent proteins and preventing the dangerous aggregation of misfolded or damaged proteins. In the brain, their protective, homeostatic role is critical for maintaining cellular integrity and preventing the accumulation of toxic aggregates associated with neurodegeneration.