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Heart Failure Pathophysiology

Meaning

Heart Failure Pathophysiology describes the complex sequence of functional and structural abnormalities that culminate in the heart’s inability to pump blood efficiently enough to meet the body’s metabolic demands. This chronic syndrome is characterized by a detrimental feedback loop involving reduced cardiac output and maladaptive neurohormonal activation. Understanding this pathophysiology is crucial for developing targeted pharmacological interventions that interrupt the cycle of cardiac deterioration. The condition involves both systolic and diastolic dysfunction.