Healthspan Trajectory Adjustment is the clinical and lifestyle intervention strategy designed to modify the rate and quality of an individual’s healthy aging process. It involves implementing personalized protocols aimed at extending the period of life spent in good health and functional capacity, distinct from merely extending total lifespan. The adjustment seeks to compress the period of morbidity at the end of life.
Origin
This concept is central to the emerging field of longevity and preventative medicine, shifting the focus from treating age-related disease to maintaining biological vitality. It is a practical application of gerontology research that identifies modifiable factors influencing biological age. The term reflects a proactive, data-driven approach to human development.
Mechanism
Adjustment protocols work by targeting the cellular and molecular hallmarks of aging, including mitochondrial dysfunction, telomere attrition, and chronic low-grade inflammation. Lifestyle modifications, such as specific exercise modalities and nutritional timing, directly modulate key endocrine regulators like sirtuins and AMPK, influencing cellular repair and stress resistance. This strategic modulation aims to optimize hormonal and metabolic pathways to maintain youthful tissue function for longer.
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