Healthspan Optimization Targets are specific, measurable physiological goals aimed at maximizing the duration of an individual’s life spent in good health, rather than merely extending lifespan. These targets often focus on maintaining optimal endocrine function, metabolic flexibility, and physical capacity.
Origin
Derived from longevity research, this term shifts the focus from simple survival to functional longevity, often drawing on biomarkers related to cellular health and hormonal balance as key performance indicators. The ‘targets’ are derived from comparative studies of exceptionally healthy aging populations.
Mechanism
Achieving these targets involves modulating key biological pathways through lifestyle modifications or targeted therapies that influence factors like insulin sensitivity, mitochondrial efficiency, and anabolic signaling. Success is tracked by monitoring markers that correlate with functional decline, aiming to compress the period of morbidity at the end of life.
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