A specialized, multidisciplinary field of research and clinical practice focused on extending the period of life spent in good health, characterized by high function, vitality, and freedom from chronic disease. Unlike simple lifespan extension, this science prioritizes the quality of later years by proactively addressing the root causes of age-related physiological decline, including hormonal dysregulation and cellular senescence. It integrates principles from gerontology, endocrinology, genetics, and personalized medicine to optimize well-being.
Origin
This scientific concept evolved from traditional gerontology, shifting the focus from merely delaying death to enhancing vitality and functional capacity during the aging process. The term highlights a clinical and research paradigm that values robust physical and cognitive function over simply achieving a high chronological age.
Mechanism
Maximization is pursued through evidence-based interventions that target the hallmarks of aging, such as modulating key metabolic pathways like insulin signaling and mTOR, and optimizing the endocrine environment. Strategies often involve precision hormone replacement, senolytic therapies, targeted nutrient supplementation, and lifestyle interventions designed to enhance cellular repair mechanisms, reduce chronic inflammation, and maintain youthful tissue integrity.
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