Healthspan Extension Protocols are comprehensive, evidence-based strategies aimed at maximizing the duration of an individual’s life spent in good health, characterized by robust physiological function and low disease burden. Within the hormonal domain, these protocols focus on optimizing endocrine signaling pathways associated with cellular maintenance, repair, and metabolic efficiency. The objective is to decelerate biological aging processes mediated by hormonal decline and chronic inflammation. We target functional longevity, not merely lifespan.
Origin
The term ‘Healthspan’ is a contemporary concept contrasting with chronological lifespan, originating in aging research to prioritize quality of life in later years. ‘Protocols’ indicates a structured, repeatable clinical application of current understanding in longevity science, often incorporating endocrinology, metabolomics, and epigenetics. It reflects a proactive clinical stance focused on preserving the functional integrity of hormonal systems throughout life.
Mechanism
These protocols operate by intervening in fundamental aging pathways, often involving the modulation of nutrient-sensing pathways like mTOR and AMPK, which are intimately linked to insulin and IGF-1 signaling. Optimizing anabolic hormone profiles, such as testosterone or DHEA, supports tissue repair and mitochondrial health, directly impacting cellular vigor. By reducing chronic oxidative stress and senescent cell burden, the overall physiological environment becomes more conducive to sustained high function, thereby extending the functional healthspan.
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