What is the Origin of Healthspan Extension Models?

The term is central to the emerging field of biogerontology and preventative medicine, distinguishing the clinical goal of health from the demographic goal of lifespan. These models are derived from longitudinal studies of centenarians and genetic research identifying pathways that confer disease resistance and delayed aging. They represent a scientific and clinical consensus on how to optimally manage the aging process.

What is the Mechanism of Healthspan Extension Models?

The models propose mechanisms centered on modulating the hallmarks of aging, including genomic instability, telomere attrition, cellular senescence, and mitochondrial dysfunction. Key interventions involve optimizing endocrine signaling pathways, such as mTOR and AMPK, through nutritional, pharmacological, and lifestyle modifications. By targeting these fundamental cellular processes, healthspan extension models aim to synchronize the biological age of various organ systems, ensuring robust function for a longer period.

Healthspan Extension Models ∞ Area

Healthspan Extension Models

Meaning

Healthspan Extension Models are theoretical and practical frameworks that outline strategies and interventions designed to increase the duration of an individual’s life lived in good health, free from significant chronic disease or disability. These models prioritize the quality of life and functional capacity over mere chronological survival, focusing on the compression of morbidity into the shortest possible period at the end of life. The clinical application of these models drives personalized longevity protocols.