The desired outcome in longevity science where the period of life lived in robust health and functional capacity is extended, effectively compressing the duration of late-life morbidity and frailty. In hormonal terms, this relates to maintaining optimal endocrine profiles well into advanced chronological age. It signifies a focus on quality of life years, not just lifespan extension.
Origin
This term is derived from longevity research, contrasting ‘lifespan’ (total years lived) with ‘healthspan’ (years lived well). Compression suggests minimizing the segment where physiological decline, often driven by hormonal insufficiency, dominates. It represents a goal-oriented approach to aging biology.
Mechanism
Healthspan compression is actively supported by maintaining hormonal balance, optimizing cellular repair mechanisms, and mitigating chronic inflammation, which often degrades tissue function. This involves ensuring adequate signaling from anabolic hormones and maintaining insulin sensitivity throughout life. The successful mechanism results in a steeper decline curve only at the very end of life, preserving vitality.
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