A proactive, integrated clinical plan designed to compress the period of morbidity at the end of life by maximizing the number of years an individual lives in good health and functional capacity. This strategy focuses on optimizing biological markers of aging, such as telomere length, cellular senescence, and mitochondrial function, rather than merely extending chronological lifespan. It is the clinical pursuit of maximizing vitality.
Origin
This concept is derived from the field of geroscience, which posits that aging is the primary risk factor for most chronic diseases, and that intervening in the aging process itself can prevent multiple pathologies simultaneously. The term “Healthspan” was coined to differentiate the quality of life extension from simple survival extension.
Mechanism
The acceleration strategy operates by targeting the molecular hallmarks of aging, employing a multi-modal approach that includes personalized nutrition, exercise mimetics, and pharmacological agents. By enhancing cellular repair mechanisms, reducing systemic inflammation, and improving metabolic flexibility, the strategy aims to slow the rate of biological decline. This concerted effort sustains youthful tissue function and preserves physiological reserve well into later life.
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