Health Span Extension Protocols are structured, evidence-based interventions designed to maximize the duration of an individual’s life spent in good health, free from chronic disease and functional decline. These comprehensive protocols integrate lifestyle modifications, targeted nutritional strategies, and pharmacological or hormonal therapies to modulate the biological processes of aging. The clinical objective is to compress the period of morbidity at the end of life, enhancing vitality and quality of living. They represent a proactive approach to longevity.
Origin
The term is derived from the field of biogerontology, which distinguishes between “lifespan” (total years lived) and “health span” (years lived in good health). “Protocols” signifies a standardized, systematic clinical approach to applying the scientific findings of aging research. This framework reflects a paradigm shift from treating disease to proactively promoting robust health.
Mechanism
These protocols primarily operate by targeting the recognized hallmarks of aging, such as genomic instability, telomere attrition, cellular senescence, and mitochondrial dysfunction. Strategies often include modulating key longevity pathways, like the mTOR and AMPK signaling cascades, to enhance cellular repair and nutrient sensing. The mechanism aims to maintain homeostatic resilience across multiple organ systems, thereby delaying the onset of age-related pathology.
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