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HDAC Inhibition

Meaning

HDAC Inhibition refers to the pharmacological or molecular blockade of Histone Deacetylase (HDAC) enzymes, a class of proteins that remove acetyl groups from histone proteins, leading to a condensed chromatin structure and subsequent transcriptional repression. By inhibiting HDACs, the chromatin structure remains open and accessible, promoting gene transcription and altering the expression profile of numerous genes, including those involved in cellular differentiation, proliferation, and apoptosis. This epigenetic modulation has significant implications in oncology and is increasingly explored in metabolic and neurodegenerative contexts.