What is the Origin of HCG Stimulation?

This therapeutic concept stems from the recognition that HCG, a hormone naturally produced by the placenta during pregnancy, shares a common alpha subunit and significant biological activity with LH. Its clinical use was pioneered in fertility medicine to substitute or supplement the natural LH surge. The term specifically refers to the use of HCG as a potent stimulus for steroidogenesis and final follicular maturation.

What is the Mechanism of HCG Stimulation?

HCG binds to the LH receptor found on the Leydig cells in the male testes and on the theca and granulosa cells in the female ovary. In males, HCG stimulation prompts the Leydig cells to significantly increase testosterone synthesis and secretion. In females, a single dose of HCG is used to trigger the final maturation of the oocyte and induce ovulation, effectively substituting the natural mid-cycle LH surge to time egg retrieval or natural conception.

HCG Stimulation

Meaning

HCG Stimulation is the clinical application of Human Chorionic Gonadotropin to pharmacologically activate the Luteinizing Hormone (LH) receptor on gonadal cells, thereby inducing the production of endogenous steroid hormones. This intervention is a critical tool in both male and female reproductive endocrinology for assessing gonadal function and for facilitating specific steps in assisted reproductive technology (ART). The action leverages HCG’s structural homology with LH to elicit a biological response.