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HCG-induced Desensitization

Meaning

HCG-induced desensitization is a physiological state where target cells, primarily Leydig cells in the testes, exhibit reduced responsiveness to human chorionic gonadotropin after prolonged or repeated exposure. This diminished cellular sensitivity results in a blunted steroidogenic response despite continued hormonal stimulation, reflecting receptor downregulation or altered post-receptor signaling.