Question 1

What is the Meaning of HCG-induced Desensitization?

Accepted Answer

HCG-induced Desensitization is a cellular regulatory process where prolonged or high-dose exposure to Human Chorionic Gonadotropin (HCG) causes the Leydig cells in the testes to become less responsive to subsequent hormonal stimulation. This temporary loss of sensitivity results in a diminished testosterone production response despite the continued presence of the stimulating hormone. It represents a classic example of receptor downregulation in endocrinology.

Question 2

What is the Origin of HCG-induced Desensitization?

Accepted Answer

This term describes a physiological adaptation (Desensitization) that is triggered by the hormone HCG (HCG-induced). It is a concept derived from the study of hormone receptor biology and signal transduction pathways. This phenomenon is a natural consequence of sustained, supra-physiological receptor activation.

Question 3

What is the Mechanism of HCG-induced Desensitization?

Accepted Answer

The mechanism involves the rapid phosphorylation of the LH/HCG receptor following high-level activation, which targets the receptor for internalization into the cell cytoplasm. This receptor downregulation effectively removes the hormone-binding sites from the cell surface, physically reducing the Leydig cell's capacity to detect and respond to HCG. Consequently, the intracellular signaling cascade responsible for testosterone synthesis is dampened, leading to reduced steroidogenesis.

HCG-induced Desensitization

Meaning

Origin

Mechanism

What Are the Long-Term Effects of HCG on Male Fertility?

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