What is the Origin of hCG for Men?

Human Chorionic Gonadotropin is a hormone naturally produced by the placenta during pregnancy, hence its name. Its clinical application in men stems from its structural and functional homology to Luteinizing Hormone (LH). Recognizing this similarity, endocrinologists adopted hCG to mimic the action of LH, thereby stimulating the Leydig cells in the testes. This approach became a crucial strategy for maintaining testicular function in the face of suppressed endogenous LH.

What is the Mechanism of hCG for Men?

The primary mechanism of hCG is to bind to the same Luteinizing Hormone (LH) receptors found on the Leydig cells within the testes. This binding mimics the natural LH signal, which is typically suppressed by exogenous testosterone, thereby bypassing the pituitary-testicular feedback loop. The stimulation of the Leydig cells prompts them to synthesize and secrete testosterone and other testicular steroids, preserving the internal testicular environment necessary for spermatogenesis.

hCG for Men

Meaning

hCG for Men refers to the clinical use of human Chorionic Gonadotropin (hCG) as a therapeutic agent in male endocrinology, primarily to stimulate endogenous testosterone production and maintain testicular size. This injectable glycoprotein hormone is often used to mitigate testicular atrophy and preserve fertility when a man is undergoing exogenous testosterone replacement therapy. It is also employed in the treatment of specific forms of hypogonadism to restore testicular function.