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Half-Life Extension

Meaning

Half-life extension is a pharmaceutical strategy employed to increase the biological half-life of a drug, particularly peptide or protein therapeutics, thereby prolonging its duration of action within the systemic circulation. This modification allows for less frequent dosing, which significantly improves patient compliance and provides more stable therapeutic concentrations over time. In the context of hormonal peptides, this translates to a more consistent physiological effect on the target tissues.