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Hair Follicle Gene Expression

Meaning

Hair follicle gene expression refers to the highly regulated, spatio-temporal transcription of genetic information within the various cell types that constitute the hair follicle unit, dictating its development, growth, and cycling. This complex molecular program involves the precise activation and repression of numerous genes, including those encoding structural proteins like keratins, signaling molecules, and transcription factors. Differential gene expression profiles characterize the distinct phases of the hair cycle—anagen (growth), catagen (regression), and telogen (rest)—and are critically influenced by local hormonal milieu and systemic factors. Analyzing these expression patterns provides clinical insights into hair disorders like alopecia.