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Gut Signaling

Meaning

Gut Signaling is the intricate, bidirectional communication network that occurs between the gastrointestinal tract, its resident microbiota, the enteric nervous system, and the central nervous system, often referred to as the gut-brain axis. This complex chemical and neurological communication influences a wide spectrum of host physiology, including mood, appetite, immune regulation, and the synthesis and metabolism of key hormones. Disruption of this signaling pathway is clinically associated with numerous systemic health issues, underscoring its role as a Core Operating System component.