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Gut-Reproductive Axis

Meaning

The Gut-Reproductive Axis is a conceptual and physiological framework describing the bidirectional communication and regulatory influence between the gastrointestinal system, particularly the gut microbiota, and the reproductive endocrine system. This complex axis involves metabolic, immune, and neural signaling pathways that collectively impact sex hormone metabolism, reproductive function, and fertility in both males and females. Dysbiosis, or an imbalance in the gut microbiome composition, can profoundly disrupt the metabolism of estrogens and androgens, potentially leading to conditions like Polycystic Ovary Syndrome (PCOS) or infertility. Recognizing this intricate connection is essential for a holistic and comprehensive approach to hormonal wellness.