What is the Origin of Gut Permeability Metrics?

This term is a clinical construct derived from cellular biology and gastroenterology, where "permeability" refers to the selective passage of substances across a membrane. The use of "metrics" signifies the transition from a theoretical concept to a quantifiable diagnostic tool. Assessing these markers is central to functional and integrative medicine approaches to chronic inflammation.

What is the Mechanism of Gut Permeability Metrics?

Increased gut permeability occurs when the tight junction proteins, like zonulin and occludin, are compromised, allowing larger molecules to pass through the paracellular pathway. This translocation of bacterial components, such as LPS, triggers an immune response and low-grade systemic inflammation. Measuring these metrics allows clinicians to gauge the effectiveness of interventions aimed at restoring barrier function and reducing inflammatory load.

Gut Permeability Metrics ∞ Area

Gut Permeability Metrics

Meaning

Objective, measurable indices used in clinical practice to assess the integrity of the intestinal epithelial barrier, often referred to as the “tight junctions.” These metrics quantify the passage of non-metabolized molecules from the gut lumen into the systemic circulation, a phenomenon known as increased gut permeability or “leaky gut.” Clinically relevant markers include zonulin, lactulose-to-mannitol ratios, and lipopolysaccharide (LPS) levels.