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Gut Permeability Management

Meaning

Gut Permeability Management is the clinical strategy focused on restoring and maintaining the integrity of the intestinal epithelial barrier, preventing the pathological passage of undigested food particles, microbial products, and toxins into the systemic circulation. This process involves strengthening the tight junctions that seal the spaces between enterocytes, which are the cells lining the gut. Clinically, excessive permeability, often termed “leaky gut,” is associated with chronic low-grade inflammation, autoimmune responses, and the dysregulation of the HPA axis. Effective management is crucial for resolving systemic inflammation and improving overall hormonal balance.