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Gut Mucus Layer Renewal

Meaning

This physiological process describes the continuous, vital turnover and restoration of the protective gel-like mucus layer that lines the entire intestinal epithelium, serving as the first, critical line of defense against luminal pathogens and various microbial toxins. A robust, adequately hydrated mucus layer is absolutely critical for maintaining the necessary physical separation between the vast gut microbiota and the host immune system residing directly beneath the epithelial cells. Impaired renewal of this layer can lead to a severely compromised barrier, directly contributing to systemic inflammation and immune dysregulation.