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Gut Microbiome Estrogen

Meaning

Gut microbiome estrogen refers to the critical, reciprocal relationship between the collective microbial community in the gastrointestinal tract and the metabolism, circulation, and eventual excretion of estrogens in the host. A specific subset of gut bacteria, collectively known as the “estrobolome,” produces the enzyme beta-glucuronidase, which deconjugates estrogens that have been tagged for excretion. This deconjugation process allows the freed, active estrogen to be reabsorbed into the circulation, directly influencing the body’s overall estrogen load and hormonal balance. Dysbiosis in this system can lead to either estrogen excess or deficiency.