The essential metabolic contribution and energy derived from the collective microbial community residing in the gastrointestinal tract, which plays a vital role in nutrient processing and overall host energy balance. This “Energy” is primarily delivered in the form of short-chain fatty acids (SCFAs), which are produced by the fermentation of undigested dietary fibers by the gut flora. Optimizing the composition and function of this microbiome is key to maximizing energy extraction and metabolic health.
Origin
This term is a modern construct within the emerging field of gut-brain-axis and metabolic research, combining the established concept of the “Gut Microbiome” with its functional role in host “Energy” homeostasis. It highlights the symbiotic relationship where the host provides a habitat, and the microbes provide essential metabolites that the host can utilize for energy.
Mechanism
The primary mechanism involves the anaerobic fermentation of complex carbohydrates that human enzymes cannot digest, leading to the production of SCFAs like butyrate, propionate, and acetate. Butyrate serves as the main energy source for colonocytes, maintaining gut barrier integrity, while propionate and acetate travel to the liver and periphery, contributing to systemic energy and lipogenesis. Hormones and neurotransmitters are also influenced by microbial activity, further integrating this energy source into the body’s overall metabolic regulation.
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