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Gut-Liver-Androgen Axis

Meaning

The Gut-Liver-Androgen Axis describes a complex, bidirectional signaling network that links the health of the intestinal microbiome and the metabolic function of the liver to the regulation and metabolism of androgens. The gut microbiome influences hormone breakdown and enterohepatic recirculation, while the liver is the primary site for androgen synthesis, conjugation, and clearance. Dysfunction in this axis, such as gut dysbiosis or non-alcoholic fatty liver disease, can significantly alter the balance of circulating testosterone and its metabolites. Clinical management often involves addressing gut and liver health to optimize endogenous androgenic signaling.