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Gut-Immune System Connection

Meaning

The Gut-Immune System Connection refers to the extensive and reciprocal communication network between the gastrointestinal tract and the host’s immune system, primarily mediated by the gut-associated lymphoid tissue (GALT), the mucosal barrier, and the resident microbiota. Approximately 70-80% of the body’s immune cells reside near the gut, making this interface a critical site for immune education, tolerance, and the initiation of inflammatory responses. The integrity of this connection is fundamental to preventing systemic inflammation and autoimmune phenomena.