What is the Origin of Gut Hormone Modulation?

The term is derived from "gut hormone," referring to the peptides secreted by the digestive tract, and "modulation," which means to influence or adjust. The recognition of the gut as a major endocrine organ responsible for integrating nutrient sensing with systemic energy regulation is the foundation of this concept. This understanding is key in the clinical management of metabolic disorders.

What is the Mechanism of Gut Hormone Modulation?

Dietary components and microbial metabolites act as powerful modulators of gut hormone release. For instance, consuming fiber and protein can stimulate the release of satiety-promoting hormones like GLP-1 and PYY. Targeted interventions aim to enhance the secretion of beneficial anorexigenic hormones while improving the sensitivity of peripheral tissues to these signals, thereby supporting balanced energy metabolism and hormonal signaling to the brain.

Gut Hormone Modulation

Meaning

Gut hormone modulation is the process of deliberately altering the secretion, activity, or receptor sensitivity of hormones produced by the enteroendocrine cells of the gastrointestinal tract. These gut hormones, such as GLP-1, ghrelin, and cholecystokinin, play a critical role in regulating appetite, satiety, glucose homeostasis, and energy balance. Therapeutic modulation is a promising strategy for metabolic health and weight management.