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Gut-Hormone-Hair Axis

Meaning

The Gut-Hormone-Hair Axis is a conceptual, integrated framework illustrating the complex bidirectional signaling and metabolic interconnections between the gastrointestinal microbiome, the entire endocrine system, and the critical hair follicle cycle and overall health. This comprehensive axis acknowledges that the gut’s microbial composition and functional capacity directly influence the metabolism and circulating levels of host hormones, which subsequently impact the growth, density, and retention of hair. Disruptions in this delicate and complex interplay can ultimately manifest as various forms of clinical alopecia or noticeable hair thinning.