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Gut Hormone Axis Signaling

Meaning

Gut Hormone Axis Signaling refers to the intricate, rapid communication pathways between the gastrointestinal tract and the endocrine system, mediated by a diverse array of regulatory peptides secreted by enteroendocrine cells. These hormones, including Glucagon-like Peptide-1 (GLP-1), Cholecystokinin (CCK), and Ghrelin, are released in response to nutrient presence and modulate systemic functions such as satiety, glucose homeostasis, and gut motility. This signaling network is a key determinant of energy balance and metabolic health, directly influencing appetite control and insulin sensitivity. Dysregulation in this axis contributes significantly to metabolic disorders.