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Gut-Hormone Axis

Meaning

The Gut-Hormone Axis represents the intricate, bidirectional communication network linking the gastrointestinal tract, its resident microbiota, and the endocrine system. This axis encompasses the signaling pathways through which the gut influences the secretion, metabolism, and action of hormones throughout the body, including those governing appetite, metabolism, and mood. It highlights the profound influence of digestive health on systemic hormonal balance, demonstrating that the health of the microbiome is inseparable from endocrine function. Dysregulation within this axis is increasingly recognized as a contributing factor to metabolic disorders, such as insulin resistance and obesity.