A limited number of bacterial species within the intestinal microbiome whose functional importance to the entire microbial community and host physiology is disproportionately high relative to their numerical abundance. Their presence is a cornerstone of a healthy gut ecosystem.
Origin
The concept of a “keystone species” is an ecological principle adapted to the gut microbiome, emphasizing that not all species contribute equally to ecosystem stability. The term highlights the functional criticality of specific microbial players.
Mechanism
These species maintain ecosystem balance by producing essential short-chain fatty acids (SCFAs), consuming niche substrates that prevent pathogen overgrowth, or regulating the local immune environment. For instance, Faecalibacterium prausnitzii is a key producer of butyrate, vital for colonocyte health. Maintaining a robust population of these keystone species is essential for modulating systemic inflammation and metabolic health.
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