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Gut Endocrine Cells

Meaning

Gut endocrine cells, also known as enteroendocrine cells, are specialized, hormone-secreting cells dispersed throughout the epithelial lining of the gastrointestinal tract, acting as the largest endocrine organ in the body. These cells sense luminal contents, such as nutrients and microbial metabolites, and respond by releasing a diverse array of peptide hormones into the circulation and locally within the gut wall. Their output is critical for regulating appetite, satiety, insulin secretion, gut motility, and overall energy homeostasis.