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Gut Derived Metabolite Influence

Meaning

Gut derived metabolite influence describes the systemic impact exerted by small, bioactive compounds produced by the enteric microbiota through the fermentation and metabolism of dietary and host-derived substances. These metabolites, such as short-chain fatty acids, secondary bile acids, and indoles, are absorbed into the circulation and act as signaling molecules that directly affect distant organs, including the brain, liver, and endocrine glands. This influence represents a critical pathway through which the gut microbiome modulates host physiology, immunity, and hormonal homeostasis.