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Gut-Brain Axis Peptides

Meaning

Gut-Brain Axis Peptides are a diverse group of short-chain amino acid compounds synthesized and released by enteroendocrine cells in the gastrointestinal tract or by neurons in the central and enteric nervous systems, acting as crucial chemical messengers between the gut and the brain. These bioactive peptides regulate a wide array of physiological functions, including appetite, satiety, mood, stress response, and gastrointestinal motility. Key examples include Ghrelin, Leptin, and Peptide YY, whose signaling is integral to metabolic and neuroendocrine homeostasis. Clinically, their dysregulation is often implicated in metabolic disorders and certain neuropsychiatric conditions.