Gut-Brain Axis Neurotransmitters refers to the complex array of signaling molecules, primarily neurotransmitters, that are synthesized or modulated within the gastrointestinal tract and participate in bidirectional communication with the central nervous system. This axis represents a vital neuroendocrine pathway linking gut health, the microbiome, and brain function. Key neurotransmitters, such as serotonin, dopamine, and GABA, are significantly produced or influenced by the enteric nervous system and gut microbiota, impacting mood, cognition, and stress response.
Origin
The understanding of this intricate connection has evolved from the historical recognition of the enteric nervous system as the “second brain” to the modern, systems-level concept of the Gut-Brain Axis. The realization that the gut microbiota directly influences neurochemistry through metabolic byproducts cemented this term in clinical and scientific literature. This field merges gastroenterology, endocrinology, and neuroscience into a unified model of systemic health.
Mechanism
The communication occurs via several integrated pathways: the Vagus nerve provides a direct neural link; microbial metabolites, such as short-chain fatty acids, act as signaling molecules; and the gut endocrine cells produce and release neurotransmitters and hormones. For instance, approximately 90% of the body’s serotonin is produced in the gut, where it regulates motility before acting as a systemic signaling molecule. This integrated chemical and neural communication allows the physiological state of the gut to profoundly influence brain function and hormonal regulation.
We use cookies to personalize content and marketing, and to analyze our traffic. This helps us maintain the quality of our free resources. manage your preferences below.
Detailed Cookie Preferences
This helps support our free resources through personalized marketing efforts and promotions.
Analytics cookies help us understand how visitors interact with our website, improving user experience and website performance.
Personalization cookies enable us to customize the content and features of our site based on your interactions, offering a more tailored experience.